地域性差异也可以影响肝脏移植手术

Researchers at the University of Michigan and Arbor Research Collaborative for Health, both in Ann Arbor, have identified geographic variation（地理性变化） as a key factor accounting for disparities（不同，不一致） in access to liver transplantation among racial and ethnic groups. Full details appear in the September issue of Liver Transplantation, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases (AASLD). Organ allocation（分配，安置） in the U.S. is designed for equitable（公平的，公正的） distribution of deceased donor organs. Patients are prioritized to receive organs for liver transplantation (LT) based on their Model for End-stage Liver Disease (MELD) score, an objective assessment of their risk of dying on the waitlist（候补名单） . Hence, two candidates with similar MELD scores should have an equal chance of receiving a transplant regardless of race, gender, geography, or economics. However, there are multiple patient-specific as well as healthcare-specific barriers to LT that potentially compromise（妥协，折衷） this system. Some of these variables include inadequate access to healthcare, lack of recognition of the need for transplant, access to a transplant center, and inequities in the transplant evaluation process.

While racial and ethnic disparities are evident throughout this entire process, the researchers found that the locale where candidates seek care for their liver disease modifies the effect of race/ethnicity on access to liver transplantation. Organ availability differs by region, and even within a region, the likelihood（可能性） of LT varies among donor service areas (DSA). Local organ availability and center specific transplant practices may also play a role.

Amit K. Mathur, M.D., M.S., and colleagues propose that racial/ethnic disparity in access to transplantation at the DSA level must be evaluated because previous studies fail to acknowledge that organ availability is highly variable across DSAs, only evaluate African-Americans as a minority, and fail to account for changes in the severity of liver disease over time while candidates are waitlisted.

The authors conducted a Scientific Registry of Transplant Recipients analysis of data submitted to the Organ Procurement and Transplantation Network (OPTN). They considered 39,114 adult chronic end-stage liver disease candidates on the waitlist between 2002 and 2007. The primary variable of interest was candidate race (74.1% Caucasian, 13.9% Hispanic, 7.3% African-American and 3% Asian) and the primary outcome of interest was transplant rates by race/ethnicity, stratified（分层） by DSA and MELD score.

The analysis reveals that without adjustment by DSA, African-Americans appeared to have a 10% lower rate of receipt of LT as compared to Caucasians. After adjustment by DSA the deficit in this rate decreased to 2% and was no longer significant, , suggesting a direct link to DSA as the source of racial disparity and that African Americans are likely over represented in DSAs with organ shortage.

In contrast, Hispanics had an 8% lower LT rate than Caucasians even after adjustment for DSA. Stratified by DSA, this difference was pronounced at a MELD score < 20 (15% lower transplant rate) but the difference was no longer present at higher MELD scores. The persistently lower rates of transplant for Hispanics even after consideration of DSA may indicate Hispanics are over represented at centers that transplant candidates at higher MELD scores. Prior studies also suggest that Hispanics are overrepresented in DSAs with longer median waiting times for LT.

Asians experienced no significant difference in liver transplant rates compared to Caucasians. On analysis of MELD subgroups, however, Asian candidates with lower MELD scores (6-14) had a 24% higher transplant rate relative to Caucasians but a lower transplant rate (15-46%) was observed at MELD scores >15, possibly due to a combination of center effect as well as donor issues such as body size. However, the overall rates of transplant were similar among Caucasians and Asians.

"Geographic variation is being increasingly recognized as a threat to optimizing the use of donated organs, and in our study had a clear effect on the measured differences in transplant rates between minorities and Whites," concluded Dr. Mathur. "We observed significantly lower liver transplant rates for minority candidates compared to their White counterparts, particularly among Hispanic candidates and Asians with high MELD scores. Importantly, these lower relative transplant rates were not accompanied by higher rates of death, removal for non-transplant reasons, and inactivation."

In an editorial also published this month, Patrick Kamath, M.D., from the Mayo Clinic concurred, "Geographic incongruence serves to undermine an organ allocation scheme（分配方式） based on equity and needs to be addressed to make complex path to LT less cumbersome（笨重的，累赘的） for persons with chronic liver disease, regardless of race, gender, payer or any other status."