某细菌基因组可能揭开水银有毒之谜

A newly sequenced bacterial genome from a team led by the Department of Energy's Oak Ridge National Laboratory could contain clues as to how microorganisms produce a highly toxic form of mercury（水银） . Methylmercury（甲基水银） , a potent human neurotoxin, appears in the environment when certain naturally occurring bacteria transform inorganic mercury into its more toxic cousin. Few bacterial species are capable of this conversion, and exactly how the transformation takes place has been a matter of debate for decades.

"What is not known are the genes or the proteins that allow these bacteria to mediate the transformation," said ORNL's Steven Brown, who led a research team to sequence the genome of a bacterium in the Desulfovibrio genus that is capable of methylating mercury.

The new genome, sequenced at the California-based DOE Joint Genome Institute (JGI) and published in the Journal of Bacteriology, lays the foundation for future research to examine the little understood mechanisms behind the production of methylmercury.

Desulfovibrio（脱磷弧菌属） desulfuricans strain ND132 is an organism that thrives in sediments and soils without oxygen – the places in lakes, streams and wetlands where mercury contamination is converted to methylmercury. It is representative of a group of organisms that "breathe" sulfate instead of oxygen and are largely responsible for mercury methylation in nature.

"This is the first Desulfovibrio genome that will methylate mercury that's been published," Brown said. "Now that we have this resource, we can take a comparative approach and look at what is different between the bacteria that can methylate mercury and those that are unable to."

The introduction of mercury into the environment primarily stems from its use in industrial processes and from the burning of fossil fuels. Although industry and regulators have worked to minimize the release of mercury, there is a legacy of mercury pollution in aquatic environments worldwide. Understanding the fundamental science behind the production of methylmercury could eventually help mitigate and reduce the impacts of mercury pollution.

"Mercury is a global contaminant of concern," Brown said. "We hope that some of the lessons we learn from these studies will be applicable（可适用的） to many sites. If we can identify the genes involved in mercury methylation, we hope to go to the local environment and understand more about the function and the ecology of the organisms and their gene products that mediate this transformation."