科学家首次定序古爱尔兰人基因组

A team of geneticists from Trinity College Dublin and archaeologists from Queen's University Belfast has sequenced the first genomes from ancient Irish humans, and the information buried within is already answering pivotal questions about the origins of Ireland's people and their culture. The team sequenced the genome of an early farmer woman, who lived near Belfast some 5,200 years ago, and those of three men from a later period, around 4,000 years ago in the Bronze Age, after the introduction of metalworking. Their landmark results are published today in international journal Proceedings of the National Academy of Sciences, USA.

Ireland has intriguing genetics. It lies at the edge of many European genetic gradients with world maxima for the variants that code for lactose tolerance, the western European Y chromosome type, and several important genetic diseases including one of excessive iron retention, called haemochromatosis. 

However, the origins of this heritage are unknown. The only way to discover our genetic past is to sequence genomes directly from ancient people, by embarking on a type of genetic time travel.

Migration has been a hot topic in archaeology. Opinion has been divided on whether the great transitions in the British Isles, from a hunter-gatherer lifestyle to one based on agriculture and later from stone to metal use, were due to local adoption of new ways or whether these influences were derived from influxes of new people. 

These ancient Irish genomes each show unequivocal evidence for massive migration. The early farmer has a majority ancestry originating ultimately in the Middle East, where agriculture was invented. The Bronze Age genomes are different again with about a third of their ancestry coming from ancient sources in the Pontic Steppe.