down and out

down and out 　失业，不走运

 
例句：

The bum was down and out on skid row.  这个流浪汉是贫民区的一个失业者。

The writer was down and out, but he still went on with his writing.  那个作家虽然已经穷困潦倒了，但他还是继续写作。